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KMID : 0352719970210020125
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Journal of Ginseng Research
1997 Volume.21 No. 2 p.125 ~ p.131
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Ginseng Inhibit Endothelium-dependent Contraction in the Spontaneously Hypertensive Rat Aorta in vitro
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Kim Nak-Doo
Kang Keon-Wook
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Abstract
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Our previous study showed that in vivo treatment of spontaneously hypertensive rats (SHR) with protopanaxatriol ginsenosides (PPT) reduces the blood pressure and inhibits the con- tractions induced by endothelium-derived contracting factor (prostaglandin endoperoxide (PGH2) and superoxide anion) in aorta isolated from SHR. The aim of the present study is to examine whether PPT improves endothelial functions in the isolated thoracic aorta of SHR in vitro. Treatments of aortic rings with PPT, purified ginsenoside Rg1 (Rg1) or indomethacin normalized endotheliuln-dependent relaxation to acetylcholine, but not with protopanaxadiol ginsenosides (PPD) and purified ginsenoside Rb1 (Rb1). The effects of PPT were dose-dependent. PGH,- and oxygen free radical-inducted contractions in rat aorta without endothelium were inhibited by PPT or Rg1, but not by PPD or Rb1. Contractions induced by PGF2α, U-46619, a stable thromboxane A2 agonist or KCI (60 mM) were not inhibited by PPT, Rg1 or Rb1. These findings demonstrate that PPT but not PPD scavenges the oxygen-derived free radicals and/or antagonize the effects of PGH2 in the vascular smooth muscle and may explain the hypotensive effect of ginseng in the SHR.
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KEYWORD
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Ginsenosides(PPT, PPD, Rg₁, Rb₁), aorta, prostaglandin endoperoxide(PGH2), superoxide anion, endothelium-dependent contraction, SHR
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